Game Details:
Matchup: Bengals vs Broncos
Date & Time: Monday, September 29, 2025 | 8:15 PM ET
Venue: Empower Field at Mile High, Denver, CO
Betting Line: Broncos -2.5 | Over/Under: 44.5
Key Storylines
Bengals Looking to Stay Hot: Cincinnati comes into this Monday night matchup riding a three-game win streak and looking like a contender in the AFC North once again. Joe Burrow has regained his pre-injury form and is connecting well with Ja’Marr Chase and Tee Higgins. The offensive line has also improved, giving Burrow more time in the pocket.
Broncos Defense Heating Up: After a shaky start to the season, Denver’s defense has tightened things up, allowing only 17.3 points per game over their last three contests. Patrick Surtain II continues to lock down opposing receivers, and the pass rush, led by Nik Bonitto and Baron Browning, has started to come alive.
Mile High Advantage: Playing in Denver is always a challenge, especially for visiting teams not used to the altitude. The Broncos are 2-0 at home this season and will look to extend that streak against a Bengals team that has struggled at times on the road.
Injury Report
Bengals:
Out: Dax Hill (shoulder), Charlie Jones (hamstring)
Questionable: Tee Higgins (rib), Logan Wilson (ankle)
Broncos:
Out: Greg Dulcich (hamstring), Jonathon Cooper (concussion protocol)
Questionable: Javonte Williams (quad)
Betting Trends
Against the Spread (ATS):
Bengals: 2-2 ATS this season
Broncos: 3-1 ATS this season
Over/Under Trends:
The total has gone under in 3 of the Bengals’ 4 games
The total has gone under in 3 of the Broncos’ 4 games
Head-to-Head:
The Bengals and Broncos last met in 2023, with Cincinnati winning 24-10 at home. However, the Broncos have historically played well at home against this franchise – winning 6 of the last 8 at Mile High.
Player Prop to Watch
Joe Mixon (Bengals) – Rushing Yards Total: 68.5
Mixon has seen an increased workload with the Bengals looking to control time of possession. With Denver susceptible to the run (ranked 25th in rushing yards allowed), the over could be in play here.
Russell Wilson (Broncos) – Passing Touchdowns: 1.5
Wilson has thrown multiple touchdowns in three straight games. With Cincinnati’s secondary banged up, the over looks attractive.
Prediction & Best Bets
Spread: Bengals +2.5 → Cincinnati’s offense is peaking, and even with the altitude factor, they have the firepower to keep this close or win outright.
Total: Under 44.5 → Both teams have leaned on ball control and defense, making a lower-scoring game likely.
Player Prop: Joe Mixon Over 68.5 rushing yards → He’s facing a weak run defense and could break a few big gains.
Final Score Prediction: Bengals 23, Broncos 20