Game Details:
Matchup: Lions vs. Ravens
Date & Time: Monday, September 22, 2025 | 8:15 PM ET
Venue: M&T Bank Stadium, Baltimore, MD
Betting Line: Ravens -3.5 | Over/Under: 48.5
Key Storylines
High-Stakes AFC vs NFC Showdown: In a must-watch Monday Night Football matchup, the red-hot Lions travel to Baltimore to take on a Ravens squad that’s been lights-out at home. Both teams come into this Week 3 clash with 2-0 records and playoff aspirations, making this game an early litmus test for contenders in each conference.
Defense vs Offense: The Lions feature a balanced attack with Jared Goff running the show, while the Ravens continue to lean on Lamar Jackson’s dual-threat dynamic, now aided by a healthier receiving corps. The battle between Detroit’s explosive offense and Baltimore’s bend-but-don’t-break defense will be a central theme.
Injury Report
Lions:
Questionable: Amon-Ra St. Brown (ankle), Brian Branch (hamstring)
Out: Jonah Jackson (thumb), Josh Paschal (knee)
Ravens:
Questionable: Marlon Humphrey (groin), Rashod Bateman (toe)
Out: Marcus Williams (pectoral), J.K. Dobbins (Achilles, season-ending)
Betting Trends
Against the Spread (ATS):
Lions: 1-1 ATS this season
Ravens: 2-0 ATS this season
Over/Under Trends:
The total has gone under in 4 of the Ravens’ last 5 home games
The over has hit in 5 of Detroit’s last 6 road games
Matchup Breakdown
Ravens’ Home Dominance: Baltimore has covered the spread in five of their last six home games and boasts one of the toughest home-field advantages in the league. Lamar Jackson is 8-2 in primetime games at home and presents a constant threat with both his arm and legs.
Lions’ Road Ambitions: The Lions surged late in 2024 and have maintained that momentum into 2025. Their rebuilt secondary faces a tough challenge containing Baltimore’s speedy receivers, but Detroit’s front seven could create problems for the Ravens’ pass protection.
Player Prop to Watch
Jared Goff – Passing Yards Total: 264.5
Goff has passed for over 270 yards in each of the first two games and could find success against a Ravens secondary that may be without its top cornerback in Marlon Humphrey.
Zay Flowers – Receptions Total: 5.5
The second-year receiver has emerged as a go-to option for Jackson. If Bateman is limited or out, expect Flowers’ usage to climb even higher.
Prediction & Best Bets
Spread: Ravens -3.5 → Back the Ravens and their home-field advantage in primetime. Lamar’s mobility and Baltimore’s balanced offense might be too much for Detroit’s defense.
Total: Under 48.5 → Both teams can score, but with key injuries and two above-average defenses, the under has value.
Player Prop: Zay Flowers Over 5.5 receptions → In Jackson’s crosshairs early and often, Flowers should see ample targets against Detroit’s zone coverage.
Final Score Prediction: Ravens 24, Lions 20