Game Details:
Matchup: Cardinals vs Seahawks
Date & Time: Thursday, September 25, 2025 | 8:15 PM ET
Venue: Lumen Field, Seattle, WA
Betting Line: Seahawks -3.5 | Over/Under: 44.5
Key Storylines
NFC West Showdown: Both teams are looking to make their mark in a competitive NFC West division early in the season. Seattle is entering this matchup with a 2-1 record, while Arizona is still searching for its first win at 0-3.
Quarterback Watch: All eyes will be on the performance of Cardinals’ quarterback Kyler Murray, who continues to play through what appears to be lingering issues with mobility following an ACL tear last season. On the other side, Geno Smith leads a balanced Seahawks offense that’s beginning to find its groove.
Defensive Concerns for Arizona: The Cardinals’ defense has allowed over 27 points per game through three weeks, putting pressure on their offense to keep up. Against a dynamic Seattle receiving corps, that could spell trouble.
Injury Report
Cardinals:
Out: Budda Baker (hamstring), LT D.J. Humphries (concussion protocol)
Questionable: James Conner (ankle), Zaven Collins (shoulder)
Seahawks:
Out: Tariq Woolen (knee), TE Noah Fant (foot)
Questionable: DK Metcalf (ribs), Kenneth Walker III (groin)
Betting Trends
Against the Spread (ATS):
Cardinals: 1-2 ATS this season
Seahawks: 2-1 ATS this season
Over/Under Trends:
The total has gone over in 2 of Arizona’s 3 games
The total has gone under in 2 of Seattle’s 3 games
Player Props to Watch
Tyler Lockett (Seahawks) – Receiving Yards: 58.5
With Metcalf nursing an injury, Lockett could see increased targets and should find success against a shaky Cardinals secondary.
Kyler Murray (Cardinals) – Rushing Yards: 31.5
Murray may be forced to use his legs more with offensive line injuries and Seattle’s pass rush applying pressure consistently.
Prediction & Best Bets
Spread: Seahawks -3.5 → Seattle’s home-field advantage and defensive edge make them the better bet in this matchup.
Total: Under 44.5 → With both teams potentially missing key weapons and Seattle’s defense capable of limiting Arizona, the under holds value here.
Player Prop: Tyler Lockett Over 58.5 Receiving Yards → Expect a solid target share and big-play potential.
Final Score Prediction: Seahawks 23, Cardinals 16